Drug Insight: If inhibitors as specific heart-rate-reducing agents

Drug forecast – the peptide deformylase inhibitors as antibacterial agents

The relatively rapid development of microbial resistance after the entry of every new antimicrobial into the marketplace necessitates a constant supply of new agents to maintain effective pharmacotherapy. Despite extensive efforts to identify novel lead compounds from molecular targets, only the peptide deformylase inhibitors (PDIs) have shown any real promise, with some advancing to phase I hu...

New Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors

  Objective(s): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards FeIII-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide. In this paper the results of a comparative study on the SLO inhibitory activities of the ...

Protease inhibitors as antiviral agents.

Currently, there are a number of approved antiviral agents for use in the treatment of viral infections. However, many instances exist in which the use of a second antiviral agent would be beneficial because it would allow the option of either an alternative or a combination therapeutic approach. Accordingly, virus-encoded proteases have emerged as new targets for antiviral intervention. Molecu...

Inotropic agents for heart failure: what if digoxin increases mortality?

Clinical Update If Current and Heart Rate Control

Understanding the mechanisms underlying the spontaneous depolarization of cardiac cell membranes, either those of the sinoatrial node or those that may have this ability, such as Purkinje fiber cells in the His bundle, has always been important, because it is the spontaneous depolarization during phase 4 of the action potential that allows these cells to determine a heartbeat, that is to say, a...